不同病理类型肾病患者尿中可溶性细胞间粘附分子-1的变化

Changes of soluble ICAM-1 level in the urine of patient with various kinds of renal disease

目的：研究尿中可溶性细胞间粘附分子－１（ｓｏｌｕｂｌｅ ｉｎｔｅｒｃｅｌｌｕｌａｒ ａｄｈｅｓｉｏｎ ｍｏｌｅｃｕｌｅ－１ｉｎ ｕｒｉｎｅ，ｕＩＣＡＭ－１）在不同病理类型肾病患者中的变化。方法：用双抗体夹心ＥＬＩＳＡ法对３０例患者的ｃＩＣＡＭ－１水平进行检测，其中１１例检测了强的松治疗前、后ｃＩＣＡＭ－１的变化；２０例健康成人作为对照组。结果：患者组ｕＩＣＡＭ－１水平显著高于对照组，微小病变肾病ｕＩＣＡＭ－１水平最高，狼疮性肾炎次之，且与尿蛋白／肌酐呈正相关；用激素治疗的１１例患者ｕＩＣＡＭ－１水平与治疗前相比均有不同程度地下降。结论：ｕＩＣＡＭ－１水平与肾脏病变类型及程度相关，似可作为判断疾病治疗疗效的参考指标之一。

Objective: To observe changes of sICAM-1 in urine(uICAM-1) of renal patients with different pathological classification. Methods: Sandwich ELISA was used to detect levels of uICAM-1 of 30 patients, among them changes of uICAM-1 of 11 patients were detected before and after treatment with Prednisone. Twenty healthy people served as controls. Results: The mean value of uICAM-1 in patient group was significantly increased than that in control group. The highest level of uICAM-1 was found in minimal change nephropathy, followed by lupus nephritis. By multiple regression analysis, uICAM-1/cr correlated with proteinuria/cr. After treatment with Prednisone in 11 patients, the levels of uICAM-1 were decreased to a certain extent. Conclusion: Detection of uICAM-1 is clinically significant. It seems to be a marker of proteinuria and one for reference index of estimating therapeutic efficacy.