丙型肝炎病毒感染与肝细胞癌

Hepatitis C virus infection and hepatocellular carcinoma

目的 :了解丙型肝炎病毒 (HCV)感染与肝细胞癌 (HCC)的关系。方法 :采用ELISA和聚合酶链反应 (PCR)对皖北地区87例肝细胞癌、80例肝硬化和 10 0名健康对照者进行乙型肝炎病毒 (HBV)、HCV血清标志和HBV DNA、HCV RNA检测。结果 :肝癌组和肝硬化组HCV感染率均显著高于对照组 (P <0 .0 1) ;肝癌组和肝硬化组肝炎病毒感染以HBV为主 ,其次为HBV和HCV重叠感染及HCV感染。结论 :皖北地区肝癌和肝硬化的发生 ,除与HBV感染密切相关外 ,与HCV感染亦密切相关。

?Objective:To explore the relationship between the infection of hepatitis C virus(HCV) and hepatocellular carcinoma(HCC).Methods:ELISA and PCR techniques were used to detect the serologic markers of HBV and HCV,HBV-DNA and HCV-RNA of 87 patients with hepatocellular carcinoma(HCC),80 patients with liver cirrhosis(LC) and 100 healthy controls from north Anhui area.Results:Both the infection rates of HCV in HCC group and LC group were significantly higher than that in healthy control group( P <0.01).It was showed that the rate of HBV infection was the higherest,the following was HBV and HCV overlapping infection and HCV infection,and non-HCV and non-HBV infection was the lowerest in both HCC group and LC group.Conclusions:It is suggested that HBV infection was associated highly with HCC and LC,and HCV infection was also associated highly with HCC and LC in north Anhui area.The overlapping infection of HCV and HBV might increase the risk of the development process of HCC. 〔