摘要
取新生大鼠小脑皮质进行体外神经细胞培养 ,用兴奋性氨基酸建立神经元变性损害模型 ,并在培养液中加入不同浓度胶质细胞衍生性神经营养因子 (GDNF) ,观察其对兴奋性氨基酸毒性的影响及受损神经元的恢复。结果表明 :在培养液中加入 GDNF可明显减轻小脑皮质神经元变性、死亡 ,并呈正量效关系。提示 GDNF可拮抗兴奋性氨基酸神经毒性 ,对小脑皮质神经元有保护。
The effects of different consistency of glial cell linederived neurotrophic factor(GDNF)on the excitatory amino acid and resumption cerebellar cortical neurons in injured cultured neonatal rat in vivo were observed.The findings were as follows:GDNF in cultures may considerably decreasd the degeneration and death of neurons with quantity-effect relationship.High density GDNF may resist the neurotoxicity of excited amino-acid and defense neurons to accelerate recovery and functioral survival.
出处
《锦州医学院学报》
2000年第1期1-3,22,共4页
Journal of Jinzhou Medical College
关键词
脊髓小脑变性
GDNF
神经元变性
兴奋性氨基酸
glial cell
line-derived neurotrophic factor
excitatory amino acid
cerebellar
nurotoxicity
