加巴喷丁联合伐昔洛韦减少带状疱疹后遗神经痛发生的疗效观察

Combination of Gabapentin and Valacyclovir Reducing the Incidence of Postherpetic Neuralgia:a Randomized Comparative Study

目的观察急性期带状疱疹患者联合加巴喷丁和伐昔洛韦治疗预防带状疱疹后遗神经痛发生的疗效。方法采用随机对照试验,将69例急性期带状疱疹患者随机分为治疗组(36例)及对照组(33例)。所有患者均给予伐昔洛韦,治疗组伐昔洛韦剂量加倍,同时加用加巴喷丁。采用视觉模拟评分法(VAS)评价患者治疗前、治疗后1、4、8周疼痛程度及治疗效果,同时观察患者的不良反应。治疗结束2个月后再电话随访一次。结果治疗组疗效明显高于对照组(P<0.05),带状疱疹后遗神经痛(PHN)发生率明显低于对照组(P<0.05)。结论急性期带状疱疹患者联合加巴喷丁和伐昔洛韦治疗可减少带状疱疹后遗神经痛发生率。

Objective To evaluate the efficacy of treatment with gabapentin plus valaeyclovir for the prevention of postherpetic neuralgia in patients with acute herpes zoster. Methods A randomized and comparative study was conducted. 69 patients with acute herpes zoster were randomly divided into treatment group （36eases） and control group （33cases）. All the patients received valacyclovir hydrochlofide. The treatment group received valacyelovir at double dose, at the same time they also received gabapentin. The visual analogue scale （VAS） was used to assess pain and treatment effect before treatment and after treatment 1, 4, 8 weeks, and the adverse reactions were observed simultaneously. They were followed up by telephone 2 months after treatment discontinuation. Results The obvious effective rate of treatment group was significantly higher than control group （ P 〈 0.05）. Incidence of Postherpetic Neuralgia in treatment group was lower than that in control group （ P 〈 0.05 ）. Conclu- sion The combination of gabapentin and valaeyelovir administered acutely in patients with herpes zoster reduces the incidence of postherpetie neuralgia.