硫酸吗啡缓释片辅助治疗癌性疼痛的疗效观察

Morphine Sulfate Sustained-release Tablets Adjuvant Treatment Efficacy of Cancer Pain

目的观察硫酸吗啡缓释片辅助治疗癌性疼痛的临床疗效。方法随机抽取69例晚期癌症患者,观察组39例应用硫酸吗啡缓释片,对照组30例应用盐酸吗啡控释片,对比两组的临床疗效。结果观察组疼痛缓解率达到92.3%(36/39),对照组疼痛缓解率为70.0%(21/30),两组比较差异有统计学意义(P<0.01)。其中观察组中维持用药剂量≤80mg/d者共27例,疼痛缓解率100%(27/27);>80mg/d者12例,疼痛缓解率75.0%(9/12)。对照组中用药剂量≤80mg/d者20例,疼痛缓解率88.9%(16/18);>80mg/d者12例,疼痛缓解率41.7%(5/12)。同等剂量硫酸吗啡缓释片与盐酸吗啡控释片的疼痛缓解率比较差异有统计学意义(P<0.05)。两组患者药物不良反应发生率比较差异均无统计学意义(P>0.05)。结论硫酸吗啡缓释片镇痛效果确切,是辅助治疗癌性疼痛的理想药物。

Objective To observe the adjuvant treatment of morphine sulfate sustained -release tablets clinical efficacy of cancer pain. Methods random sample of 69 cases of advanced cancer patients, observed group of 39 patients were treated with sustained- release morphine sulfate tablets in the control group, 30 patients were treated with morphine hydrochloride con- trolled - release tablets, 30mg/12h, 2 times / d, compared two groups of clinical efficacy. Results The pain relief rate of 92. 3% （36/39） , response rate compared with the control group there was a significant difference （P 〈 0.01 ）. Conclusion The analgesic effect of morphine sulfate tablets exactly, adjuvant treatment of cancer pain is an ideal drug.