4种抗生素治疗下呼吸道感染药学探析

Pharmacy analysis of four antibiotic in the treatment of lower respiratory infection

目的探讨4种抗生素治疗下呼吸道感染的药学效果。方法将180例下呼吸道感染患者随机分为A组、B组、C组及D组各45例。A组给予左氧氟沙星治疗,B组给予阿奇霉素治疗,C组给予头孢唑肟治疗,D组给予头孢曲松治疗。比较4组治疗效果、不良反应及花费。结果各组显效率比较差异无统计学意义(P>0.05);4组均未出现严重不良反应;A组花费700元,B组1523.2元,C组1052.1元,D组742元,药费比较:A组vsD组(P>0.05),B组vsC组(P<0.05),B组vsA组及D组(P<0.01),C组vsA组及D组(P<0.05)。结论 4种治疗方案治疗下呼吸道感染均有较确切的疗效,但头孢曲松和左氧氟沙星治疗下呼吸道感染从药学经济、合理用药的角度考虑更为理想。

Objective To investigate the pharmacy effect of four kinds of antibiotics in the treatment of lower respiratory infection. Methods 180 cases patients with lower respiratory infection were randomly divided into group A,group B, group C and group D, each of 45 cases. Group A were given levofloxacin treatment, group B was treated with azithromycin treat- ment, group C were given ceftizoxime treatment, group D received ceftriaxone treatment. Compared treatment effect, adverse reaction and cost of four groups. Results The efficiency rate of each group were no statistically difference （P 〉 0. 05 ） ; No serious adverse reactions in 4 groups;To spend, 700yuan in group A, group B 1523.2yuan, group C 1052.1 yuan, group D 742 yuan. Group A vs group D （ P 〉 0. 05 ）, group B vs group C （ P 〈0. 05 ）, group B vs group A and D （ P 〈 0. 01 ）, group C vs group A and D （ P 〈 0. 05 ）. Conclusion Four kinds in the treatment of lower respiratory infection are more precise efficacy, but ceftriaxone and levofloxacin in the treatment of lower respiratory infection to consider more desirable from the perspective of the pharmaceutical economy, rational use of drugs.