不同长度的石棉诱发大鼠胸膜间皮瘤的比较

Experimental Study on Incidence of Mesothelioma Caused by Asbestos Fibres of Verious Length

本文用不同产地不同长度的石棉给大鼠胸腔内注入染尘,实验分10组,染尘剂量各组均为50mg/只,仅有一组短纤维青石棉为30mg/只,对照组等量生理盐水。观察各组的间皮瘤发病率,结果指出:各组石棉,不论长、短纤维均能诱发间皮瘤,短纤维发病率在50%左右,长纤维在70%以上,长纤维较短纤维的发病率明显升高(P<0.05～0.01),UICC 石棉与我国应用的石棉发病串相似,UICC 玻璃纤维的发病串也很高为71.4%,存活时间,各实验组大鼠较对照组短100天左右。

Ten experimental groups of rats were inoculated intrapleurally with asbes-tos of various length from different sources are described.Tbe dose was 50mgper rat,except in one group of short fibre crocidolite was inoculated 30mg perrat.Sterile physiological saline was used in the control grorp.The incidence of mesothelioma in each group was observed.The result in-dicated that asbestos produced mesothelioma in all experimental groups.Theincidence was lower (about 50%) in short fibre asbestos group and higher inlong fiber groups (over 70%).The incidence of UICC asbestos was similar with that used to ourcountry.UICC glass fibre also produced mesothelioma and the iucidence washigh (71.4%).The mean survival time of all experimental groups was around 100 daysshorter than that of the control grorp.