辛伐他汀联合吡喃阿霉素对肝癌SMMC-7721细胞的协同抑制作用

The effect of simvastatin plus priarubicin on proliferation of liver cancer cell line SMMC-7721

目的:研究辛伐他汀联合吡喃阿霉素对人肝癌细胞SMMC-7721的增殖抑制作用。方法:辛伐他汀、吡喃阿霉素分别及联合处理细胞48小时,MTT法测量细胞的增殖抑制,按公式计算相互作用指数。结果:按照文献报道计算相互作用指数,相互作用指数小于1。结论:辛伐他汀和吡喃阿霉素对于SMMC-7721有协同抗瘤作用。

Objective：To examine the interaction effect of simvastatin and priarubicin on proliferation ability of SMMC -7721. Methods：After treated SMMC -7721 cell with simvastatin and priarubicin 48 hours, proliferation of SMMC- 7721 were examined with MTT test. Results：The interaction index for simvastatin and priarubicin used in combination in SMMC -7721 was 0.71. Conclusion ：The combination therapy with simvastatin and priarubicin may be due to the synergistic interaction of these two drags.