姜黄素对复发难治性急性髓细胞白血病患者血清VEGF、survivin表达水平影响

Effect of curcumin capsules on the expression level of serum VEGF and survivin in refractory and relapsed acute myeloid leukemia patients

目的:研究姜黄素对复发难治性急性髓细胞白血病患者治疗效果及其可能作用机理。方法:酶联免疫法检测复发难治急性髓细胞白血病患者在不同治疗组中,治疗前后血清VEGF及survivin表达水平。结果:复发难治性急性髓细胞白血病患者血清VEGF、survivin表达水平较对照组显著升高,经过姜黄素胶囊联合化疗治疗后,患者血清VEGF、survivin表达水平显著下降,较单纯化疗组下降更明显,二者差异有统计学意义(P<0.05)。对难治及复发急性白血病患者缓解率影响,二者差异无统计学意义(P>0.05)。结论:姜黄素胶囊联合化疗能显著降低复发难治急性髓细胞白血病患者血清VEGF、survivin表达水平,在抑制急性白血病进展上有一定作用。

Objective：To study the effect of curcumin on refractory and relapsed acute myeloid leukemia and its possible mechanism. Methods：By using ELISA to test the expression level of serum VEGF and survivin in different treatment groups before and after treatment on refractory and relapsed acute myeloid leukemia patients. Results：In re- fractory and relapsed acute myeloid leukemia patients, serum VEGF and survivin expression levels were significantly higher than the control group. The expression levels of serum VEGF and survivin were significantly decreased in Cur- cumin capsules combination with chemotherapy treatment group, compared with chemotherapy alone. There were sta- tistically significant differences（ P 〈0.05）. Conclusion： Curcumin capsules combined with chemotherapy can signifi- cantly reduce the expression level of serum VEGF and survivin in refractory and relapsed acute myeloid leukemia pa- tients.