须重视干性年龄相关性黄斑变性的研究

Paying attention to the research on dry age-related macular degeneration

干性年龄相关性黄斑变性（AMD）是老年人最常见的不可逆性致盲眼病，在中国的发病率逐渐增加，部分患者在疾病进展过程中可转化为湿性AMD，严重影响视功能，给患者个人及其家庭和社会带来了极大的经济负担。AMD发病机制尚不明确，目前认为与光损伤、氧化应激、视网膜脂褐素沉积和免疫因素等有关。迄今为止，有效的预防和治疗AMD的方法仍是研究的热点，近年来针对AMD的药物研究包括抗氧化药物、减少细胞外沉积物的药物和抗炎药物的基础和临床应用研究正在进行中。随着中国人口老龄化速度的加快，必须促进对干性AMD发病机制的研究，重视诊断技术归人探索和普及，提高预防意识，加深治疗方法的探讨，以达到对AMD进行预防和早期干预的目的。

Dry age-related macular degeneration （ AMD ） is a prevalent form of irreversible blindness worldwide in the elderly population with an increasing incidence in China. It is found that some dry AMD will develop to wet AMD and therefore damage visual function. Pathogenesis of AMD is below understand now,but it is thought to be related to the light-induced ocular damage,oxidative stress response, extraeellular disposition and immunology. Up to now,effective and safe prevention and treatment methods of AMD are still studying, especially wet AMD, but the concern on dry AMD is not enough. Some basic and clinical pharmaceutics researches on AMD include antioxidants, anti-extracellular disposition drugs and anti-inflammatory agents. With the rise of aging population, we should pay special attention to the research on pathogenesis, diagnosis and treatment of dry AMD.