几种络合剂的驱铅效果实验

Experimental Study on the Efficacy of Several Chelating Agents to Remove Lead

小鼠一次或多次腹腔注射醋酸铅后,分别投给DMSA、Na_2CaEDTA、DPA、Na_3CaDTPA 和DMPS 测定这几种络合剂降低肝、肾、脾、骨和脑组织铅含量的效应。结果发现,在一些实验条件下,用络合剂处理后小鼠肝、肾、骨和脑铅含量明显低于对照组。检测的几种络合剂中,不论腹腔注射还是胃管注入DMSA,其从组织中驱铅的能力均比其它种络合剂更有效。结果提示这种络合剂是有发展前途的,值得临床上深入研究。

The efficacy of Dimercaptosuccinic acid (DMSA),Disodium calciumethylendiaminetetraacetate (Na_2CaEDTA),D-penicillamine (DPA),Trisodiumcalcium diethylenetriaminepentaacetate (Na_3CaTPA) and Sodiumdimercaptopropane sulfonate (DMPS) to reduce liver,kidney,spleen,bone andbrain levels of lead was determined in mice given either a single or repeated in-jections of lead acetate.In the chelating agents examined,the ability of DMSAadministered either by intraperitoneal injection or by oral garage to removelead from tissue was far more effective than other chelating agents.The resultsindicated that DMSA may be a promising chelating agent worthy of furtherclinical investigation.