扑热息痛的光化学荧光特性及其分析应用

Photochemically-induced Fluorescence of Paracetamol and Its Analytical Application

研究了扑热息痛（ＰＲ）的在线光化学荧光特性。发现丙酮可提高ＰＲ的光化学反应速率并增强其光化学荧光强度；反应介质的ＰＨ值（７．７～１１．２）对光化学反应的速率影响不大，但对光化学荧光的强度影响明显。以含有０．０４％丙酮的ＰＨ９．６硼砂硼砂缓冲液作为反应介质，建立了流动注射在线光化学荧光测定扑热息痛的新方法，检测限（３σ）为１９μｇ／Ｌ，相对标准偏差为０．６％，分析速度达６０次／ｈ。

The charecteristics of on-line photochemically- induced fluorescence of paracetamol wasinvestigated. It was found that acetone significantly increased the rate of the photochemical reaction andin turn the photochemically-induced fluorescence- intensity, and that the acidity of sample solution in therange of pH 7. 7 ~ 11. 2 had no significant effect on the reaction rate but greatly affectecd thefluorescence-intensity. Based on the observation, a spectroflurimetric method with flow injection on-linephotochemical reaction for the determination of paracetamol was developed. Using a pH 9. 6 borate buffersolution containing 0.04% acetone as the reaction medium, a detection limit of 19μg/L was achieved atthe sample throughput rate of 60/h. Eleven determinations of a 0. 5 mg/L paracetamol standard solutiongave a RSD of 0. 6% - The developed method was successfully used to determine the paracetamol contentsin some pharmacutical preparations.