荷移反应用于测定烟胺羟丙茶碱

Application of Charge Transfer Reaction to the Determination of Xanthinol Nicotinate

烟胺羟丙茶碱与茜素红在水溶液中发生电行转移反应，生成2：1型络合物，此络合物的λmax=539nm，表观摩尔吸光系数是2．72×103L·mol－1·cm-1，药物浓度在5－150mg／L范围内符合比尔定律，相对标准偏差为0．81％（n=6），回收率在97％以上。应用拟定的方法测定药物制剂的含量，结果与紫外分光光度法一致。

A spectrophatometric method for the deternination of xanthino nicotinate has been developed based on the charge transfer reaction. Beer's law is obeyed in the range of 5 ~ 150 mg/L of xanthinol nicotinate. The apparent molar absorptivity of complex at 539 nm is 2. 72×103L·mol-1· cm-1. The average standard deviation of sir determinations is 0. 8%. The present method has been applied to the determiantion of xanthinol nicotinate in tablets with satisfactory results.