丙二酰氧基硼氢化钠介入的醛、酮还原胺化反应

Reductive amination of aldehydes and ketones mediated by sodium malonyloxyborohydride

叙述了在原位生成的丙二酰氧基硼氢化钠存在下的醛、酮还原胺化反应。讨论了还原胺化的反应条件和立体位阻效应，发现丙二酰氧基硼氯化钠是一个高选择性还原剂，在给定条件下不发生自身还原反应。

The reductive amination of aldehydes and ketones with amines in the presence of sodium malonyloxyborohydride 1 prepared in situ from malonic acid and sodium borohydride in anhydrous THF is described. The reaction conditions and the steric hindrance effect for the reductive amination are also discussed. It was found that self-reduction of 1 did not occur under the experimental conditions.