摘要
叙述了在原位生成的丙二酰氧基硼氢化钠存在下的醛、酮还原胺化反应。讨论了还原胺化的反应条件和立体位阻效应，发现丙二酰氧基硼氯化钠是一个高选择性还原剂，在给定条件下不发生自身还原反应。
The reductive amination of aldehydes and ketones with amines in the presence of sodium malonyloxyborohydride 1 prepared in situ from malonic acid and sodium borohydride in anhydrous THF is described. The reaction conditions and the steric hindrance effect for the reductive amination are also discussed. It was found that self-reduction of 1 did not occur under the experimental conditions.
出处
《化学试剂》
CAS
CSCD
2000年第2期65-67,共3页
Chemical Reagents
基金
国家自然科学基金!2937206
武汉市晨光青年科学基金!93CGB0204
关键词
丙二酰氧基硼氢化钠
醛
酮
胺
还原胺化
sodium malonyloxyborohydride
aldehyde
ketone
amine
reductive amination
