1例肾综合征出血热死亡病例分子流行病学分析

Molecular epidemiology analyze of a hemorrhagic fever with renal syndrome case

目的分析2011年广州市1例肾综合征出血热重症死亡病例的发病原因,并对其进行分子流行病学分析。方法将患者血清以及居住地周围人群、老鼠标本进行抗体检测和PCR检测,将获得的序列与NCBI上的序列进行比对。结果鼠血IgG抗体检测阳性率为33.33%,人群血清IgG抗体检测阳性率为5.66%,均高于检测的阳性率。患者血清中汉坦病毒基因不存在大的变异。结论加强HFRS的日常监测,扩大监测范围和数量,认真做好防鼠灭鼠工作,减少传染源,切断传播途径,有利于HFRS的防治。

Objective To find out the cause of a hemorrhagic fever with renal syndrome case,and carry out molecular epidemiology analyze.Method The serum samples were developed antibody and PCR detection among the patient,surround people and rat.Acquired sequence compare with the sequences in the Genbank.Results The positive rate of IgG in the sera of rats and people were 33.33% and 5.66%,respectively,they were higher than the positive rate we survey in these years.Hantavirus was not big mutation in the patient＇s serum.Conclusions We need to enhance the daily surveillance,expand the monitoring circumsciption and quantity,do well the deratization work,reduce the infection sources,cut down the transmission routes,those were profit for HFRS.