慢性心力衰竭患者肌钙蛋白I和室性心律失常及近期预后的关系

Correlation of Cardiac Troponin I with Ventricular Arrhythmia and Late Prognosis in the Patients with Chronic Heart Failure

目的:研究慢性心力衰竭(CHF)患者血清心肌肌钙蛋白I(cTnI)和室性心律失常及近期预后的关系。方法:174例CHF患者分为2组:cTnI阳性组(A组)78例和cTnI阴性组(B组)96例。所有患者均行24h动态心电图监测,并观察随访住院期间和出院后6个月内不良心脏事件发生率、再住院率和死亡率。结果:A组平均每h单个室性早搏,成对室性早搏总数,24h室性心动过速的次数均明显高于B组的CHF患者(P<0.01);A组住院期间和出院后6个月内不良心脏事件发生率、因不良心脏事件的再住院率和死亡率均明显高于B组(P<0.05)。结论:血清cTnI浓度与CHF患者室性心律失常及近期预后有关,对判断估测老年CHF患者预后有警示作用。

Objective：To investigate correlation of cardiac troponin I（cTnI） with ventricular arrhythmia and late prognosis in the patients with chronic heart failure（CHF）.Methods：The levels of serum cardiac troponin I（cTnI） of 174 patients with chronic heart failure（CHF） were detected.The patients were divided into two groups： cTnI-postive group（A group） with serum cTnI≥0.16ng/ml（n=78） and cTnI-negative group（B group） with serum cTnI〈0.16ng/ml（n=96）.Ventricular arrhythmia was assesed by 24h Holter monitoring in two groups.The incidence of adverse cardiac events,re-hospitalization mortality during the period of in-hospital and the 6 months of out-ofhospital were observed and followed up.Results：Mean hourly number of single ventricular premature beats,Mean hourly ventricular pairs,and the frequency of ventriclar tachycardia episodes per 24h in A group were significantly higher than those in B group（all P〈0.01）;during the period of observation and follow-up,the incidence of adverse cardiac events,re-hospitalization and mortality of patients in A group were significantly higher than those in B group（all P〈0.05）.Conclusion：Serum cTnI levels correlated with ventricular arrhythmia and late progonis,which could be used as a prognosis predicting for patients with CHF.