原发性肝癌组织及血清中GP73的表达及其临床意义

Expressions and clinical significance of GP73 in primary liver carcinoma and serum

目的:分析原发性肝癌(primary liver carcinoma,PLC)患者组织及血清GP73变化,探讨其临床意义。方法:采用免疫组化SP法检测组织中GP73的表达,Elisa法检测血清GP73。结果:PLC组织中GP73阳性率82.5%,较其癌旁组织50.0%及肝血管瘤手术患者的肝组织37.0%明显升高(P<0.05),差异有统计学意义;HLC患者血清GP73含量明显高于检测的其他肝病患者和健康志愿者血清GP73,差异有显著性(P<0.05)。结论:GP73是原发性肝癌的潜在肿瘤标记物。

Objective： To investigate the expression of GP73 in primary liver carcinoma （PLC） tissues and serum, as well as its clinic significance. Methods： The expression of GP？3 was assessed by immunohistochemistry in tissues and double antibody enzyme linked immunosorbent （Elisa） in serum. Results： The positive ratio of GP73 in PLC 82.5 % were significantly higher than both the adjacent tissue 0.0% and the normal tissues 37.0%, P〈0.05. And there was significant difference in level of serum GP73 among the patients with PLC, the patients with hepatic diseases and the normal controls, especially higher in the patients with PLC （P〈0.05）. Conclusion： GP73 is the potential tumor marker of PLC.