1049例妇科门诊病人HPV感染基因型分析

Analysis of human papilloma vivus infection genotypesof 1049 clients in department of gynecology

目的研究宝安区妇女感染HPV的优势亚型,为宫颈癌防治提供依据。方法利用HPV基因芯片检测技术检验我院妇科门诊样本HPV亚型。结果 1049例病人中,HPV感染264例,阳性率25.17%。其中高危型(HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、和MM4)162例,占感染者81.44%;低危型(HPV11、6、42、43)49例,占感染者18.56%。二组感染率比较差异有统计学意义;264例感染HPV优势亚型HPV52,其次依次为16、43、58、68、18、53型;<30岁及≥30岁两年龄段HPV感染率比较差异无统计学意义;组间优势亚型分布比较HPV53在<30岁年龄组明显增加,其他优势亚型分布比较差异无统计学意义;单一亚型感染239例,占90.52%。结论高危亚型、单一亚型为主要常见感染类型;HPV基因分型诊断在宫颈癌筛查和防治中具有重要意义。

Objective： To investigate the predominant genotypes of human papiliomavirus （HPV） genotype affect in 1049 women in Shenzhen city, Baoan Distract to provide theoretical basis of preventing and treating uterine cervical cancer. Methodes： 1049 sampies were detected for HPV genotype by using DNA hybridization technique. Rusults： 264 cases were HPV, with theposition rate of 25.17% , 162 cases belonged to high- risk type, with the ratio of 81.44% in HPV position cases, 49 cases for loe -risk type, with the ratio of 18.56%, Subtype HPV 52 occupied the frist of all types, followed by subtype 16, 43, 58, 68, 18, 53. By the comparison in accordance with the disparity in 〈 30 and 330 agesection, macculine gender rate has no significance difference after the Chisquare test. The predominant HPV genotype in 〈 30groups was HPV53. The distribution of the others predominant HPV genotype has no difference after the chisqaare test in two age groups. 239 cases were the single HPV genotype with the artio of 90. 53%. Conclusions ： High - risk single tenotype in the most common HPV infection type, and HPV52 is the major subtype, the third predominant HPV genotype was HPV43. HPV genotype have significances for screening, prevention and care of cervical cancer.