孕妇血清ADAM12-S水平与妊娠结局的相关性研究

Maternal serum ADAM12-Slevels and the correlation of pregnancy outcome

目的探讨妊娠早期孕妇血清解整合素-金属蛋白质酶12(ADAM12-S)水平变化与唐氏综合征等妊娠结局的关系。方法应用时间分辨荧光免疫分析法检测早孕期(8-11周)孕妇血清中ADAM12-S水平,并分析ADAM12-S水平变化与唐氏综合征等妊娠结局的关系。结果正常单胎血清ADAM12-S水平随孕周增加而逐渐上升的趋势,且呈线性相关(r=0.993,P<0.01)。唐氏综合征等非整倍体染色体异常的ADAM12-S水平的明显低于正常单胎孕妇,差异有统计学意义(P<0.05).结论早孕期孕妇血清中ADAM12-S水平随孕周增加而上升,可用于非整倍体常染色体异常的筛查,预测胎停育、异位妊娠等早期妊娠丢失,可作为产前筛查指标。

Objective： To investigate maternal serum during early pregnancy disintegrin - metal protease 12 （ADAM12 -S） levels and Down＇s syndrome pregnancy outcome. Methods： The time -resolved fluorescence immunoassay test early pregnancy （8 -11 weeks ） maternal serum levels of ADAM12 - S, and analysis of ADAM12 - S levels and Down＇s syndrome pregnancy outcome. Results： The serum ADAM12 - S single fetus with gestational age increased levels gradually rise, and the linear correlation （ r = 0. 993, P 〈 0. O1 ）. Down syndrome and other aneuploid chromosome abnormalities ADAM12 - S levels were significantly lower than the normal single fetus of pregnant women, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion： The maternal serum in early pregnancy the level of ADAM12 - S increased with increasing gestational age, can be used for aneuploidy screening for chromosomal abnormalities often predict tire stop infertility, ectopic pregnancy, such as early pregnancy loss, prenatal screening can be used as Indicators.