浙江省台州地区167例男性不育的染色体畸变及生殖激素水平研究

Study chromosome aberration and reproductive hormone levels for 167 cases of male infertility in Taizhou Zhejiang Province

目的研究男性不育与染色体畸变及生殖激素水平关系。方法对167例男性不育患者进行染色体核型分析和精液常规检测,用电化学发光法测定生殖激素水平。结果不育男性患者染色体异常发生率为10.8%(18/167),其中性染色体异常占7.2%(12/167),常染色体异常占3.6%(6/167)。染色体核型异常患者FSH、LH均不同程度升高,而T水平偏低;染色体核型正常无精子症组FSH、LH显著高于少弱精子症与对照组,少弱精子组也显著均高于对照组,另四项T、PRL、E2、P三组间不存在差异。结论染色体异常是造成男性不育重要因素,而生殖激素水平能反映不同程度的生精障碍,对男性不育者有必要进行细胞遗传学检查和生殖激素检测。

Objective： To study chromosome aberrations and reproductive hormone levels for male infertility Methods： Karyotype, semen routine testing and reproductive hormone levels were detected from 167 cases of male infertihty. Results： The proportion of ab- normal chromosome was 10. 8% in the cases of male infertility, with abnormal sex chromosome for 7. 2% （12/167） and abnormal autosomal for 3.6% （6/167）. FSH, LH were elevated to varying degrees in Chromosome abnormalities patients, while the T level is low; FSH, LH of chromosome azoospermia in normal karyotype group were significantly higher than Oligoasthen/azoospermic and the control group, Oligoastherr/azoospermic group were also significantly higher in the control group, and the T, PRL, E2, P did not differ among the three groups. Conclusion： Chromosome abnormalities are an important factor in causing male infertility and reproductive hormone levels can reflect the different degrees of impaired spermatogenesis.