小剂量低分子肝素治疗儿童急性早幼粒细胞白血病DIC的临床观察

Research of low-dose low molecular weight heparin therapy for acute promyelocytic leukemia(APL) in children with disseminated intravascular coagulation

目的:探讨小剂量低分子肝素治疗急性早幼粒细胞白血病弥漫性血管内凝血(DIC)的疗效及其安全性。方法:初次接受治疗的40例急性早幼粒细胞白血病(APL)患儿随机分成两组,小剂量低分子肝素治疗组(A组)20例,常规治疗组20例,比较两组的DIC发生率和完全缓解率。结果:低分子肝素治疗组DIC的发生率较常规治疗组低(P<0.05),而完全缓解率差异无统计学意义(P>0.05)。结论:小剂量低分子肝素可以有效减少急性早幼粒细胞白血病患儿DIC的发生,具有良好的安全性。

Objective：To investigate curative effect and security of low-dose low molecular weight heparin ther- apy for acute promyelocytic leukemia （APL） in children with disseminated intravascular coagulation. Method= For ty cases were randomized into two groups, 20 cases were treated with low-dose low molecular weight heparin therapy （group A）, 20 cases were treated with conventional therapy （group B）. Result： The cases which transformed into disseminated intravascular coagulation （DIC） in group A were significantly lower than group B （P〈0.05）. There was no significant difference of the rate of complete remission between group A and B. Conclusion=Low-dose low molecular weight heparin therapy can effectively prevent the development of DIC and has satisfactory safety.