孕妇孕中期唐氏综合征筛查血清AFP、Free-β-HCG、uE3中位数倍数的临床意义

Clinical significance of MOM of maternal serum AFP、 Free-β-HCG、uE3 in second-trimester Down′s sydrome screening

目的探讨孕中期唐氏征筛查检查中AFP、Free-β-HCG、uE3中位数倍数(MOM)结果与胎儿染色体异常及其他先天畸形的关系。方法回顾性分析2009.1-2010.1在我院接受孕中期唐氏征筛查并成功随访的4250例单胎孕妇血清学筛查MOM(multiples of median)值结果与胎儿染色体异常及其他畸形发生情况。结果在4250例孕妇中,共筛查出有MOM值异常404例,其中染色体异常7例,神经管缺陷及其他畸形14例。血清学MOM值正常孕妇中发现21-三体1例,其他胎儿畸形13例,两组比较,胎儿染色体异常及其他畸形发生率有显著差距。结论孕中期血清学筛查指标MOM值异常对胎儿染色体异常,神经管缺陷及其他先天异常的发现均有一定的预测价值。

Objective： To investigate the relationship between MOM of maternal serum AFP、Free-β-HCG、uE3 in second-trimester and fetal chromosomal abnormalities and the other congenital deformity.Methods： A retrospective analysis about serologic screening of pregnant MOM（multiples of median） value in the second trimester and fetal chromosomal abnormalities and other malformationsin was performed,including 4250 single fetal cases with Down′s screening and follow-up in 2009.1-2010.1 in our hospital.Results： In these cases,there were 404 cases with the abnormal value of MOM,7 cases of chromosome abnormalities,and neural tube defects and other malformation in 14 cases.There was 1 cases of Trisomy 21 symdrome and 13 cases of the other fetal malformation in pregnant women with normal Serum MOM values.The two groups had significant difference in the rate of chromosomal abnormalities and other malformation.Conclusion： the abnormal value of MOM in the second trimester is related to fetal chromosomal abnormalities、neural tube defects and other congenital abnormalities.