不明原因复发性流产与精子DNA完整性的关系

Relationship between the prognosis of pregnancy for patients with recurrent spontaneous abortion and sperm DNA integrity

目的探讨不明原因复发性流产与男方精子DNA完整性的关系。方法精子DNA完整性检测采用精子染色质扩散试验(sperm chromatin dispersion,SCD),以DNA断裂指数(DNA fragmentation index,DFI)表示。分别对不明原因复发性流产男方与无流产史男方精子进行精液常规分析和DFI分析。结果流产组精子密度、活动率、前向运动率和DFI与生育组比较差异有统计学意义(P<0.05)。结论不明原因复发性流产可能与精子DNA损伤存在一定关系。

Objectives： To explore the relationship of sperm DNA integrity with unexplained recurrent spontaneous abortion （URSA）. Methods： Sperm DNA integrity was evaluated by sperm chromatin dispersion （SCD）, and the results were expressed interms of DNA fragmentation index （DFI） . Semen parameters, teratozoo - spermia and DFIs were measured in the male partners of women with URSA and that of without URSA. Results ： a significant difference in the concentration and mobility and forward mobility and DFI of sperm between the recurrentm iscarriage group and normal fertility group （ P 〈 0. 05 ）. Conclusion ： There is a relationship between sperm DNA damage and URSA.