摘要
目的探讨孕11-13+6周超声检查中颈项透明层增厚的胎儿与畸形风险增加的关系。方法孕周11-13+6周孕妇,经腹超声检查,测量胎儿颈项透明层厚度≥3mm的病例共60例,对60例胎儿进行介入性产前诊断,进行染色体核型分析,随访妊娠结局及新生儿情况。结果 60例颈项透明层增厚胎儿中,共发现异常胎儿17例,占28.3%(17/60)其中9例胎儿为非整倍体染色体核型,8例染色体正常胎儿在后续超声随访中出现异常胎儿畸形,预后不良。结论颈项透明层增厚是胎儿染色体异常的重要指标,在早期胎儿畸形筛查及产前检查中有十分重要的临床意义。以颈项透明层增厚作为早期干预的依据,可以使介入性产前诊断更具有针对性。
Objective ： The emphasis on clinical ending in fetuses of nuchal translucency incrassation between 11 - 13 ＋6 week made out that when NT thickend , the risks of fetal abnormal chromosome and fetal anomaly were significantly increased. Method： Throuth abdomen ultrasonic examination, to collect 60 cases of fetal nuchal translucency ≥3mm between 11 - 13＋ 6 week , we do interventionprenatal diagnosis and karyotype analysis of the fetus, follow - up the pregnancy outcome and the situation of the newborns. Result ： In the 60 cases of fetal nuchal transhlcency incrassation, we found 17 fetues abnormality （28. 3% ）, in which , 9 cases were aneuploid karyotype, 8 cases were normal karyotype, fetal anomaly came out in the follow - up study, and the prognosis was poor. Conclusion ： Nuchal translucency incrassation is an important index for fetal chromosomal abnormality and it is important for clinic in prenatal screen of fetal anomaly and prenatal examination in first trimester. With the help of nuchal translucency, it makes intervention？ prenatal diagnosis more nichetargeting in early intervention.
出处
《中国优生与遗传杂志》
2012年第7期80-82,共3页
Chinese Journal of Birth Health & Heredity
关键词
早孕期
胎儿颈项透明层
产前诊断
染色体
First trimester
Nuchal translucency
Prenatal diagnosis
chromosome
