121例冻融胚胎移植周期回顾性分析

Analysis of 121 frozen-thawed embryo transfer cycles

目的探讨影响冷冻胚胎复苏移植妊娠率的因素。方法收集2010年01月到2011年12月份在本中心进行冷冻胚胎解冻移植121个周期的资料,进行回顾性分析。结果 (1)121个周期中有35个周期获临床妊娠,周期临床妊娠率为28.92%;(2)妊娠组与非妊娠组间解冻后胚胎的优质胚胎率有显著性差异(P<0.05);(3)自然周期和激素替代周期间妊娠率无显著性差异(P>0.05),但在激素替代周期中妊娠组与非妊娠组间E2水平有显著性差异(P<0.05);(4)D2及D3冷冻胚胎复苏移植,妊娠率上亦无显著性差异(P>0.05)。结论优质胚胎是冻融胚胎移植周期获得妊娠的关键,在激素替代周期中较高的雌激素水平更有利于胚胎的着床。

Objective： To investigate the impact factors on frozenthawed embryo transfer （FET） outcomes. Methods： The data of 121 FET cycles from January 2010 to December 2011 were collected and analyzed retrospectively. Results： （ 1 ） 35 cycles wined clinical pregnancy in 121 cycles, and the pregnancy rate per cycle was 28.92% ; （2） The good quality embryo had obvious difference between pregnancy group and the no pregnancy group （P 〈 0. 05 ） ; （3） The pregnancy rate had no significant difference between natural cycle and hormone replacement cycle （ P 〉 0.05 ）, but of which E2 level had obvious difference between pregnancy group and no pregnancy group （ P 〈 0. 05 ） ; （4） Whenever D2 embryo or D3 embryo were frozen and thawed, the pregnancy rate had no significant difference （P 〉 0. 05）. Conclusion： The good quality embryo had significant impact on the FET outcome, and the higher E2 levels were benefit of embryo implanting in the hormone replacement.