血液灌流对急性重型胰腺炎患者部分炎性因子的影响

Effect of hemoperfusion on part of infammatory interleukins in patients with severe acute pancreatitis

目的:探讨早期血液灌流对急性重型胰腺炎(SAP)患者血清炎性因子的作用。方法:20例SAP患者在常规治疗基础上采取血液灌流治疗,比较治疗前、后血清白介素18(IL-18)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平及临床症状转归。并与同期未行血液灌流22例SAP患者比较。结果:血液灌流治疗后血清IL-18、TNF-α、CRP均比治疗前明显降低(均P<0.05);患者体温、心率、呼吸较治疗前降低(均P<0.05),住院天数比常规治疗组缩短(P<0.05)。结论:血液灌流能有效清除SAP患者血清IL-18、TNF-α,改善患者预后,提高早期抢救成功率。

Objective：To investigate the effect of early hemoperfusion on part of infammatmy intereukins in patients with severe acute pancreatitis （SAP）. Methods ：Twenty patients with SAP were received hemoperfusion on the basis of routine treatments. Levels of IL-18 ,TNF-α, CRP were compared before and after treatment. Meanwhile they were compared with those of SAP patients without hemoperfusion. Results：Levels of IL-18, TNF-α, CRP were significant decreased after treatment than before treatment（P 〈 0.05）; Patient＇s temperature,heart rate and respiratory rate were decreased, and days of hospitalization was shortened than those of routine treatment group （ P 〈 0.05 ）. Conclusions ： Hemoperfusion can effectively eliminate the serum IL-18 and TNF-α,and it can improve the prognosis and early successful rescue rate.