摘要
Genetically modified animal models have been used widely to model human diseases for the purposes of investigating pathogenesis and developing therapeutic strategies. The genetic modification technology consists mainly of gene tar- geting and transgenic approaches, and genetic engineering to target genes in animals has now advanced to new technologies, such as zinc-finger nuclease （ZFN） and transcription activatorlike effector nuclease （TALEN）. However, most animals used for creating disease models are still mice or other small animals.
Genetically modified animal models have been used widely to model human diseases for the purposes of investigating pathogenesis and developing therapeutic strategies. The genetic modification technology consists mainly of gene tar- geting and transgenic approaches, and genetic engineering to target genes in animals has now advanced to new technologies, such as zinc-finger nuclease （ZFN） and transcription activatorlike effector nuclease （TALEN）. However, most animals used for creating disease models are still mice or other small animals.
