凝血纤溶指标测定在冠心病中的应用价值

The value of Detecting the coagulation fibrinolysis in the coronary artery disease

测定了 2 1例急性心肌梗塞 (Acute myocardial infarction,AMI)、2 8例不稳定心绞痛(Unstable angina pectoris,UAP)和 2 0例正常对照者的血清纤维蛋白原 (Fibrinogen,Fg)、血浆 D-二聚体 (D- Dimer)、组织型纤溶酶原激活物 (Tissue- plasminogen,t- PA)及其抑制物(Plasminogen activator inhibitor,PAI)活性 ,并观察了 AMI患者溶栓前后它们的变化。结果 :1AMI、UAP患者血浆 t- PA活性降低 ,PAI活性增高 ,D- Dimer、Fg含量增多 ,提示凝血纤溶系统功能异常在冠心病 (CHD)发病中有重要作用 ,UAP和 AMI有共同的血栓倾向或血栓形成机制。 2 AMI患者溶栓后血清 Fg含量下降 ,D- Dimer含量升高 ,t- PA活性增强 ,PAI活性下降 。

In order to make clear the relationship between the change of coagulation fibrinolysis and the developing,treatment effects of coronary heart disease (CHD),serious fibrinogen (Fg) was measured ,plasimic D Dimer,tissue type plasmiogen activator (t PA) and its inhibitor plasminogen activator inhibitor (PAI) by using Enzyme Assay Meter in 21patients with acute myocardial infarction(AMI) ,28 with unstable angina pectroris(UAP) and 20 control subjects,the changes of the four indicators before and after thromboclasis in patients with AMI were also examined.The results showed that:①In the patients with AMI and UAP, the activity of plasmic t PA decreased while PAI increased, the levels of D Dimer and Fg were higher.which indicated the system of coagulation fibrinolysis played an important role in the developing of CHD because of the trend and forming of thrombus in UAP and AMI;②After thromboclasis ,the levels of serious Fg were lower, D Dimer were higher ,the activity of t PA increased while the activity of PAI decreased, which were close related to recanalization of coronary infarction.