肝硬化上消化道大出血患者血中LPO含量的动态变化及其意义

Dynamic changes and significance of plasma lipid peroxide in liver cirrhosis patients with massive upper gastrointestinal hemorrhage

观察了 51例肝硬化患者合并上消化道出血后血中过氧化脂质 (LPO)含量的动态变化及其与病情的关系。结果发现 :所有患者血 LPO含量均升高 ,以出血后腹水形成或增多和诱发肝性脑病者明显 ,显著高于对照组 (P <0 .0 5) ;死亡 8例 ,血 LPO值均 >1 1 nmol/L;LPO值 72 h达高峰 ,此时约 75%患者活动性出血已控制。

The dynamic changes of plasma lipid peroxide (LPO) levels in 51 cases of liver cirrhosis patients with massive upper gastrointestinal hemorrhage(UGH) were observed.The results showed that the LPO levels of all patients increased, especially in patients with formation or enlargement of ascites and appearance of hepatic encephalopathy after bleeding.Their levels of LPO were much higher than those of controls (P<0.05);8 patients died,their blood levels of LPO all are higher than 11nmol/L.72 h after bleeding,the plasma LPO levels of patients reached its climax while the bleeding of 38 cases (75%) were controlled.This suggests that the lipid peroxidation produced by liver ischemia and reperfusion may plays a role in deteriorating of patients′ conditions after bleeding.