手术后早期腹腔内β粒子内照射治疗进展期胃贲门癌近期疗效观察

Observation of short term efficaciousness of postoperative early perfusion with βparticle in abdominal cavity in patients with advanced cardiac-gastric carcinoma

目的 :对进展期胃贲门癌术后早期腹腔 β粒子内照射治疗的方法及疗效进行评价。 方法 :35例进展期胃贲门癌患者 ,於术中完成切除吻合程序后 ,将软硅胶管置于上腹腔瘤床部位 ,经上腹壁戳孔引出 ,缝合固定 ,术后一周消化道功能恢复后开始治疗 ,将3 2 P胶体 148～ 2 2 2MBq(4～ 6mCi)与生理盐水 (2 5 0～ 5 0 0ml)混合经导管注入腹腔。结果 :腹腔内照射组 1、2、3年生存率分别为 :82 86 %、77 14%、6 8 5 7%。术后静脉化疗组 1、2、3年生存率分别为 76 6 7%、5 6 6 7%、43 33%。结论 :进展期胃贲门癌术后早期腹腔内 β粒子内照射疗法是一种安全可靠 ,效果肯定 ,毒副反应轻微 ,简单易行的治疗方法。

Objective:To evaluate the method and effect of the treatment with βparticle infussion in abdominal cavity for postoperative patients with advanced cardiac gastric carcinoma Methods: Thirty five patients with advanced cardiac gastric carcinoma received silicone gel tube implantation in the tumor bed in upper abdominal cavity intraoperatively Following body incission, the outer end of the tube was fixed through the skin opening of the abdominal wall One week after operation, when alimentary tract function returns to normal, 32 P Colloidal 148～222MBq (4～6mCi) mixed with physiological saline was infused into the abdominal cavity through the tube The patients received iutravenous chemotherapy following sugery were used as control Results: Survial rates for 1,2 and 3 years were 82 86%, 77 14%and 68 57%in colloid group and 76 67%, 56 67%and 43 33%in intravenous chemotherapy group, respectively Conclusion:βparticle perfusion in abdominal cavity for the patients with advanced cardiac gastric carcinoma is a safe, reliable and simple adjuvant therapy with mild side effects