硬膜外布比卡因和吗啡对胃肠功能恢复的影响

Effects of epidural analgesia with bupivicaine and morphine on recovery of gastrointestinal function

目的 :探讨术后不同硬膜外镇痛用药对胃肠功能恢复的影响 ,并观察两组不同药物的镇痛效果及对生命体征的影响。方法 :40例择期妇科手术病人随机分为 3组 ,术毕M组 (n =15 )硬膜外镇痛用药为吗啡 ,B +M组 (n =15 )为 0 12 5 %布比卡因 +吗啡 ,而C组 (n =10 )无硬膜外镇痛。观察术后第一次排气和排便的时间 ,并分别记录镇痛后第 12h、2 4h、36h、48h时的疼痛评分心率、血压、呼吸和肠鸣音进行对比。结果 :(1)B +M组排气排便时间缩短 ;(2 )两组硬膜外镇痛效果均良好 ,对生命体征影响小 ,且两组间无差别。结论 :硬膜外灌注适量布比卡因 +吗啡可能对胃肠功能恢复有一定的促进作用 ,镇痛效果良好 ,安全可行。

Objective:To evaluate the effects of epidural analgesia with bupivicaine and/or morphine on recovery of gastrointestinal function and the effects on pain control and the vital signs Methods:Forty female patients scheduled to undergo pelvic operation were randomited in a double blind fashion to one of three treatment groups after operation Patients in group M (n=15) were given epidural infusions of morphine; Patients in group B+M (n=15) received 0 125%bupivicaine plus morphine and the others in group C (n=10) weren't given epidural analgesia The time to first flatus and feces were observed Pain scores on a visual analogue scale, HR, BP, R and bowel sounds were also recorded at the 12 th, 24 th, 36 th, 48 th hour after the anelgesia, respectively Results:The time to first flatas and feces in group B+M was shorter than group C ( P< 0 05 ) Both of epidural analgesia groups resulted in excellent postoperative analgesia and the influrence to the vital signs was mild Conclusions:The use of epidural analgesia with 0 125%bupivicaine morphine is a safe and, reliable method, and it could accelerate postoperative recovery of gastrointestinal function