调强放疗在子宫颈癌中的研究进展

The progress of intensity-modulated radiation therapy (IMRT) for treatment of cervical carcinoma

放射治疗是子宫颈癌治疗中的重要方式之一,传统体外放疗方式为全盆2野对穿放疗和(或)4野放疗,此种照射野包含了小肠、直肠、膀胱、脊髓等,导致消化系统、泌尿系统等急慢性并发症发生率较高,严重影响了患者的生活质量。调强放疗具有分别调节肿瘤靶区和降低邻近危及器官剂量的优势,使宫颈癌术后补充放疗、主动脉旁淋巴结转移的根治性放疗等成为可能,同时很好地保护了危及器官,临床近期疗效满意,毒副反应可以耐受。

Radiotherapy is one of the most common treatments for cervical carcinoma. The conventional radiation therapy techniques involve either the whole pelvic 2 or 4 fields. This treatment region contains small intestine, rectum, bladder and bone marrow, so quality of life of patients are bad because of side-effects of digestive tract and urinary system. Intensity- modulated radiation therapy （IMRT） can deliver a specified dose to the clinical target volume （CTV） and a reduced dose to the adjacent organs at risk. It makes possible to supplementary radiotherapy after hysterectomy and paraaortie lymph node metastasis. The adjacent organs at risk are well protected and the preliminary clinical result is encouraging.