冠心病患者血清超敏C反应蛋白与胱抑素C水平的临床研究

The clinical study of the serum high-sensitivity C-reactive protein and cystatin C level in coronary heart disease patients

目的探讨血清超敏C反应蛋白(hs-CRP)与胱抑素C(CysC)检测在冠心病患者中的临床意义。方法选取冠心病患者100例,其中急性心肌梗死(AMI组)32例,稳定型心绞痛(SA组)30例,不稳定型心绞痛(UA组)38例,另选取同期健康体检者30例作为对照组,检测各组空腹血hs-CRP与CysC水平。结果 AMI组、UA组及SA组血清CysC水平均高于对照组(P<0.05),UA组患者血清CysC水平明显高于SA组(P<0.05);UA组与AMI组相比CysC水平差异无统计学差异(P>0.05);AMI组和UA组CRP水平较对照组均显著增高(P<0.05),SA组与对照组比较,差异无统计学意义(P>0.05);相关分析提示,在冠心病患者中血清hs-CRP与CysC水平呈正相关(r=0.659,P<0.01)。结论联合检测血清hs-CRP与CysC水平对冠心病患者的临床分型及其严重程度评估提供了重要的实验室依据。

Objective To investigate the clinical significance of the serum high-sensitivity C-reactive protein （hs-CRP） and cystatin C （CysC） detection in patients with coronary heart disease. Methods One hundred patients with coronary heart disease, including acute myocardial infarction （AMI group） 32 cases , stable angina （SA group） 30 cases and unstable angina （UA group） 38 cases, 30 healthy examiners as the control group, each group was detectde the fasting blood levels of hs-CRP and CysC. Results The serum CysC levelsvof AMI group, UA group and SA group were higher than the control group （P 〈 0.05）, the levels of serum CysC were significantly higher than the SA group （P 〈 0.05）; the level of CysC in both UA group and AMI group was not statistically significant （P 〉 0.05）; CRP levels in the AMI group and UA group were higher than the control group （P 〈0.05）, otherwise CRP levels in both SA group and control group, has no statistically significant difference（P 〉 0.05）;The serum levels of hs-CRP was positively correlated with the serum levels of CysC in the coronary heart disease patients （r = 0.659, P 〈 0.01）. Conclusion The combined detection of serum hs-CRP and CysC level was very important for the clinical type and severity assessment of the coronary heart disease it also can provide the important basis for the laboratory .