摘要
目的探讨Survivin和Cyclin D1在涎腺多形性腺瘤中的表达及其相关性。方法用免疫组织化学S-P法检测45例腮腺多形性腺瘤组织中Survivin和Cyclin D1的表达情况,并作相关性分析。结果 Survivin和Cyclin D1的表达在腮腺多形性腺瘤较正常腮腺组织明显增加,差异有统计学意义(P<0.05);Survivin和Cyclin D1的阳性表达呈正相关(r=0.550,P<0.01)。结论 Survivin和Cyclin D1在涎腺多形性腺瘤中表达增加,二者之间呈正相关,提示它们在涎腺多形性腺瘤的发生中起着重要作用。
Objective To investigate the expression of survivin and cyclin DI in salivary pleomorphic adenoma and to anal- yse the correlation between their protein expressions. Methods Immunohistochemical method was used to analyze protein expression of survivin and cyelin D1 in forty-five cases of parotid gland pleomorphic adenomas. Results There were signif- icant statistical differences of survivin and cyclin Dlexpressions in parotid gland pleomorphic adenoma tissue and normal parotid gland tissue （P 〈 0.05）; The positive expressions of survivin and cyclin D1 in salivary pleomorphie adenoma offer direct correlation （r = 0.550, P 〈 0.01）. Conclusion The expressions of survivin and eyclin D1 increase in the salivary pleomorphic adenoma. Due to their positive correlation, both of them may play important roles in the salivary pleomorphie adenoma.
出处
《中国现代医生》
2012年第18期37-38,40,共3页
China Modern Doctor
