尼莫地平对高血压性脑出血患者血肿量及预后的影响

The impact of Nimodipine on hematoma volume and prognosis of hypertensive intracerebral hemorrhage

目的观察尼莫地平对高血压性脑出血患者血肿量及预后的影响。方法 42例高血压性脑出血患者随机分为对照组和治疗组各21例,分别于治疗前后比较两组的血肿量及神经功能缺损评分的变化。结果治疗组血肿量较对照组减少更显著(P<0.05)。两组治疗1周后的神经功能缺损评分均较治疗前明显降低,且治疗组较对照组降低更显著(P<0.05)。两组治疗2周后神经功能缺损评分均分别较治疗前及治疗后1周明显降低,且治疗组较对照组降低更显著(P<0.05)。结论尼莫地平能明显降低高血压性脑出血患者的血肿量,明显改善患者的预后,值得推广和应用。

Objective To explore the impact of Nimodipine on hematoma volume and prognosis of hypertensive intracere- bral hemorrhage. Methods Selected 42 cases hypertensive intracerebral hemorrhage patients randomly divided into control and treatment group （nimodipine）, each group had 21 cases, hematoma volume and neurological deficit scores were compared between two groups. Results Hematoma volume significantly reduced compared with before treatment, and hematoma vol- ume of the treatment group decreased more significantly compared with the control group, the difference was significant （P 〈 0.05）. The neurological deficit score of two groups after treatment one week was significantly lower than before treatment, and the treatment group decreased more significantly （P 〈 0.05）. The neurological deficit scores after treatment two weeks sig- nificantly reduced compared with before treatment and after one week,and the treatment group decreased than the control group more significantly, the difference was significant（P 〈 0.05）. Conclusion Nimodipine can significantly reduce the amount of hypertensive intracerebral hemorrhage in patients with hematoma, significantly improve patient outcomes.