10天序贯疗法根除幽门螺杆菌疗效分析

Efficacy of 10-day sequential therapy for eradicating helicobacter pylori

目的观察10 d序贯疗法治疗幽门螺杆菌(Hp)的疗效和副反应,并与10 d标准三联疗法相比的优越性。方法将212例经胃镜确诊为慢性胃炎及消化性溃疡且Hp阳性的患者随机分组:治疗组108例,前5 d给予兰索拉唑及阿莫西林,后5 d给予兰索拉唑、克拉霉素、替硝唑;对照组104例,给予10 d兰索拉唑、阿莫西林、克拉霉素。结果治疗组Hp根除率93.52%,对照组Hp根除率80.77%(χ2=7.75,P<0.01);两组不良反应发生率相当,无明显差异。结论 10 d序贯疗法幽门螺杆菌根除率高,不良反应轻,可作为初始幽门螺杆菌根除选择方案。

Objective To compare the efficacy and adverse effects of Hp eradication with 10-day sequential therapy and 10-day standard triple therapy. Methods Two hundred and twelve consecutive patients with Hp positive chronic gastritis were randomly divided into two groups. 108 cases in the treatment group received sequential therapy, Lansoprazole plus Amoxicillin for the first 5 days, followed by Lansoprazole, Clarithromyein and Tinidazolc for the next 5 days. 104 cases in the control group received 10-day standard triple therapy, Lansoprazole, Amoxieillin and Clarithromycin for 10 days. Re- sults The percentage of eradication of the disease in the treatment group was 93.52%, while that in the control group was 80.77%. It had statistically significant difference between the two groups （P 〈 0.01）. But there was no significant difference in the frequency of adverse effects between two groups. Conclusion The lansoprazole based 10-day sequential therapy could achieve higher eradication rate of Hp compared with the standard triple therapy, meanwhile it has a very high safety profile for Hp eradication therapy,which could be used as first-line therapy.