β-受体阻滞剂对高血压病患者血浆肾素水平的影响及意义

Effect and Significance of β-Receptor Blocker on Plasma Renin Concentration in Patients with Hypertension

将 8 0例轻中度高血压病患者随机分成四组 , 组 (对照组 )服β-受体阻滞剂 4周 ; 、 、 组先分别服血管紧张素转化酶抑制剂 (ACEI)、利尿剂、ACEI和利尿剂 4周 ,再加服 β-受体阻滞剂 4周 ;各组均于用药前后测血浆肾素浓度。结果显示 , 、 、 组用 ACEI、利尿剂、ACEI和利尿剂后 ,其血浆肾素浓度较用药前明显提高 (P<0 .0 0 1) ,加用β-受体阻滞剂后 ,三组血浆肾素浓度均显著下降 (P<0 .0 0 1) ; 组用β-受体阻滞剂后血浆肾素浓度也明显下降 (P<0 .0 0 1)。提示β-受体阻滞剂可防治ACEI、利尿剂所致的血浆肾素浓度的升高。

out patients with mild to moderate hypertention were divided into 4 groups randomly Group Ⅰ(n=20)as control using monotherapy(β blocker)for 4 weeks Group Ⅱ,Ⅲ,Ⅳ were treated using angiotensin converting enzyme inhibitors(ACEI)(n=20),diuretics(n=20),and combination(ACEI+diuretics,n=20)for 4 weeks respectively Afterwards,the latter 3 groups were treated combinating with β blocker additionally Blood samples were obtained before and at the end of using the drugs The plasma concentration of renin in group Ⅱ,Ⅲ,Ⅳ increased significantly after using ACEI,diuretics or bother(P<0 001),but decreased greatly after using β blocker(P<0 001) The plasma concentration of renin in group Ⅰ,after using β blocker,was also decreased greatly(P<0 001) It suggests that β blocker may be used to prevent the upregulation of renin by treated with ACEI and diuretics