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MODELING THE IMPACT OF VOLUNTARY TESTING AND TREATMENT ON TUBERCULOSIS TRANSMISSION DYNAMICS

MODELING THE IMPACT OF VOLUNTARY TESTING AND TREATMENT ON TUBERCULOSIS TRANSMISSION DYNAMICS
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摘要 A deterministic model for evaluating the impact of voluntary testing and treatment on the transmission dynamics of tuberculosis is formulated and analyzed. The epidemio- logical threshold, known as the reproduction number is derived and qualitatively used to investigate the existence and stability of the associated equilibrium of the model system. The disease-free equilibrium is shown to be locally-asymptotically stable when the reproductive number is less than unity, and unstable if this threshold parameter exceeds unity. It is shown, using the Centre Manifold theory, that the model undergoes the phenomenon of backward bifurcation where the stable disease-free equilibrium co- exists with a stable endemic equilibrium when the associated reproduction number is less than unity. The analysis of the reproduction number suggests that voluntary tuber- culosis testing and treatment may lead to effective control of tuberculosis. Furthermore, numerical simulations support the fact that an increase voluntary tuberculosis testing and treatment have a positive impact in controlling the spread of tuberculosis in the community.
出处 《International Journal of Biomathematics》 2012年第4期127-145,共19页 生物数学学报(英文版)
关键词 TB model case findings treatment reproductive number stability. 动力学建模 结核病 治疗 传播 检测 地方病平衡点 确定性模型 中心流形理论
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