摘要
线粒体钙离子摄入对能量生成、细胞分裂和死亡均具有十分重要的作用,但对该过程的机制却知之甚少。最近研究鉴定出线粒体钙离子单向转运蛋白(MCU,mitochondrial calcium uniporter)和线粒体钙离子摄入蛋白1(MICU1,mitochondrial calcium uptake 1),这两种蛋白都定位于线粒体内膜,均参与钙离子摄入。MCU拥有两个跨膜结构域,显示出钙离子通道活性并对钌红敏感,而MICU1具有两个典型的EF手形结构域,该结构可感知钙离子的变化,可能作为MCU调节蛋白发挥作用。这些研究进展对线粒体内稳态的理解和线粒体相关疾病的治疗具有重要意义。
Mitochondrial Ca2＋ uptake plays an important role in energy production, cell division and death. However, its mechanism was poorly understood. Recently, mitochondrial calcium uniporter （MCU） and mitochondrial calcium uptake 1（MICU1） have been identified in several researches. Both proteins are located in the mitochondrial inner membrane and involved calcium uptake. MCU has two transmembrane domains and shows channel activity, which is sensitive to ruthenium-red. MICU1 has two canonical EF hands that are essential for calcium sensing, and may be a regulator of MCU. These progresses are beneficial for the understanding mitochondrial Ca2＋ homeostasis and the treatment of mitochondrion related diseases.
出处
《生命的化学》
CAS
CSCD
2012年第3期228-230,共3页
Chemistry of Life
