高速泳动族蛋白1的致炎症作用机制

The proinflammatory mechanism of high mobility group box 1

高速泳动族蛋白1(high-mobility group box 1,HMGB1)是一种高度保守的DNA结合蛋白,具有维持核小体结构和调节基因转录的功能,近来发现它是炎性反应强有力的促炎因子。在大多炎性疾病,特别是脓毒症病例中,HMGB1的血清和组织水平均显著升高,而且它与其受体如糖基化终末产物受体(receptor for advanced glycation end products,RAGE)、Toll样受体4(toll-like receptor,TLR4)、Toll样受体2(TLR2)等相互作用促进炎性疾病的发展。为了进一步了解HMGB1,本文就HMGB1的结构、生物学活性、与免疫细胞相互作用、细胞表面受体、以及拮抗HMGB1的药物等进行综述。

High-mobility group box 1 （HMGB1）, a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription, was recently found to act as a potent proinflammatory cytokine during infection responses. The levels of HMGB1 increase in serum and tissues during infection, especially in sepsis. HMGB1 interacts with its receptors such as receptor for advanced glycation end products （RAGE）, Toll-like receptor 4 （TLR4）, Toll-like receptor 2 （TLR2）, etc., and promotes the development of inflammatory diseases. To further understand the characteristics of HMGB 1, the structure, biological activity, interaction with immune cells, cell surface receptors and antagonists of HMGB 1 were introduced in this paper.