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蛇毒丝氨酸蛋白酶结构与功能关系

Advances on the relationship of structure and function of snake venom serine proteinases
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摘要 蛇毒丝氨酸蛋白酶(snake venome serine proteinases,SVSP)是分布于多种蛇毒中的一类蛋白质水解酶,它们与凝血及纤溶系统关系密切,具有一定的临床应用价值。本文主要介绍了几种空间结构已知的SVSP在结构上的特征,以及由此而产生的底物特异性及生化特性的差异,显示了天然SVSP中存在着与功能相关的结构变异多样性,这为进一步开发及医学利用SVSP提供了有益的信息。 Snake venom serine proteinases （SVSPs） belong to an important class of proteolytic enzyme in many kind of snake venom. They are closely related to the blood coagulation and fibrinolysis system and have potential application values in the clinic practice. Based on known tertiary structures, we review the differences of the substrate specificity, the relationship of the structure and the function of different SVSPs, so as to provide information for the future exploitation and application in the medical field.
作者 裴剑竹 杨章民
机构地区 陕西师范大学生命科学学院
出处 《生命的化学》 CAS CSCD 2012年第3期282-286,共5页 Chemistry of Life
基金 国家自然科学基金项目(30870303) 陕西省自然科学基金项目(SJ08C102) 中央高校基本科研业务费专项资金项目(GK200902029)资助
关键词 蛇毒丝氨酸蛋白酶 结构 种类 功能 SVSP structure classes function
分类号 Q55 [生物学—生物化学]
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参考文献37

  • 1Serrano SM et al. Snake venom serine proteinases: sequence homology vs substrate specificity, a paradox to be solved. Toxicon, 2005, 45:1115-1132.
  • 2牛立文,滕脉坤,朱中良,高永翔,张平.若干蛇毒蛋白的结构生物学研究[J].中国科学技术大学学报,2008,38(8):909-922. 被引量：5
  • 3Valefiano-Zapana JA et al. Functional and structural characterization of a new serine protease with thrombin-like activity TLBan from Bothrops andianus (Andean Lancehead) snake venom. Toxicon, 2012, 59:231-240.
  • 4Santana R et al. Protein folding in simplified models with estimation of distribution algorithms. IEEE Trans Evol Comput, 2008, 12:418-438.
  • 5Zhu Z et al. Crystal structures and amidolytic activities of two glycosylated snake venom serine proteinases. JBiol Chem, 2005, 280:10524-10529.
  • 6Murakami MT et al. Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator. J Biol Chem, 2005, 280:39309-39315.
  • 7Siigur E et al. A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 2011, 93: 321-330.
  • 8Siigur Jet al. Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Proeedia Chemistry, 2010, 2: 109-115.
  • 9Oyama E et al. Substrate specificity of two thrombin like enzymes (elegaxobin, elegaxobin Ⅱ) from the venom of Trimeresurus elegans (Sakishima-habu), using neutralizing antibody. Toxicon, 2006, 48:601-610.
  • 10Oyama E et al. Amino acid sequence of a kinin-releasing enzyme, KR-E-1, from the venom of Agkistrodon caliginosus (Kankoku- mamushi). Toxicon, 2008, 52:651-654.

二级参考文献92

  • 1华慧,周思翔,王正荣.组织激肽释放酶家族、激肽释放酶-激肽原-激肽系统及其重要应用[J].国外医学（生物医学工程分册）,2004,27(5):301-305. 被引量：5
  • 2王心民 戚正武.浙江蝮蛇(Agkistrodon halys Pallas)蛇毒激肽释放酶I的分离纯化及其性质的研究.Acta Biochinica et Biophysica Sinica（生物化学与生物物理学报：英文版）,1984,16(1):15-25.
  • 3Yousef GM, Diamandis EP. An overview of the kallikrein gene families in humans and other species: emerging candidate tumour markers [J]. Clin biochem, 2003, 36(6) : 443 -452.
  • 4韦传宝 陈建智.蛇毒蛋白组分的鉴定.中国毒蛇学,1995,:370-370.
  • 5Wang YM, Wang SR, Tsai IH. Serine protease isoforms of Deinagkistrodon acutus venom: cloning, sequencing and phylogenetic analysis [J]. Biochem J, 2001, (354) : 161 - 168.
  • 6Watanabe L, Shannon J D, Valente R H, et al. Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities [J]. Protein Sci, 2003,12(10): 2 273-2 281.
  • 7Lou Z, Hou J, Liang X, et al. Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus[J]. J Struct Biol, 2005,152(3): 195-203.
  • 8Bode W, Gomis-Ruth F X, Stockler W. Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the ‘metzincins' [J]. FEBS Lett, 1993, 331 (1-2):134-140.
  • 9Gong W, Zhu X, Liu S, et al. Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metatloproteinase from the snake venom of Agkistrodon acutus[J]. J Mol Biol, 1998, 283 (3): 657-668.
  • 10Takeda S, lgarashi T, Mori H, et al. Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold [J]. EMBO J, 2006,25(11): 2 388-2 396.

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生命的化学
2012年 第3期

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