摘要
报道一种通过溴代和氟代的一锅法操作,从苯乙酮直接制备α-氟代苯乙酮的新方法.使用1,3-二溴-5,5-二甲基海因(DBDMH)作为溴代试剂,三乙胺三氟化氢作为氟代试剂,除了p-和m-硝基苯乙酮之外,α-氟代苯乙酮以82%~87%的收率被获得.本方法使用的试剂价廉、收率较高、操作简单方便,有较高的应用价值.
A novel synthetic method of α-fluoroacetophenones directly from acetophenones via one-pot reactions of bromina-tion and fluorination is reported.Based on the nucleophilic fluorination,using 1,3-dibromo-5,5-dimethylhydantoin(DBDMH) as brominating reagent,triethylamine tris(hydrogen fluoride) as fluorinating reagent,α-fluoroacetophenones were obtained from acetophenones in 82%~87% total yields,except p-and m-nitroacetophenones.The proposed method has a high applica-tion value,because of its simplicity,low cost and good yields.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第6期1146-1149,共4页
Chinese Journal of Organic Chemistry