HLA-F研究进展

Research advances of HLA-F

人类白细胞抗原(human leucocyte antigen,HLA)复合体是人体中基因多态性最高的基因复合体,其多态性与疾病遗传易感性显著相关。人类白细胞抗原-F(human leucocyte antigen-F,HLA-F)属于非经典HLA I类分子中的一员,与HLA-E、-G在结构上十分相似,具有有限的多态性。近年来多数学者聚焦于HLA-F基因转录及分子表达调控、HLA-F表达与临床相关性及HLA-F抗体研制,且取得了重要成果。就HLA-F的研究进展作一综述。

Human leukocyte antigen complex with the highest gene polymorphisms in human,is significantly associated with genetic susceptibility to diseases.Human leukocyte antigen-F belongs to the non-classical HLA I molecules.HLA-F,HLA-E and HLA-G have a similar structure and a limited polymorphism.In recent years,transcription regulation of HLA-F,expression regulation of HLA-F in cell surface,clinical relevance of HLA-F and the preparation of anti-HLA-F,are widely studied and have achieved important results.In the present review,the research advances on HLA-F are discussed.