胰腺星状细胞活化相关的信号转导通路

The signaling pathways in pancreatic stellate cells

胰腺纤维化是慢性胰腺炎(chronic pancreatitis,CP)和胰腺癌主要的病理学特征,活化的胰腺星状细胞(pancreatic stellate cells,PSCs)是公认的致胰腺纤维化的主要效应细胞。PSCs的活化涉及到几个重要的信号转导通路:有丝分裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)、磷酯酰肌醇3激酶(phosphatidylinositol 3-kinase,PI3K)=、Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ(PPAR-γ)、Rho-ROCK等细胞内信号途径。探讨这些信号通路在胰腺纤维化中所起的作用对慢性胰腺炎、胰腺癌及糖尿病的治疗有重要意义。现就与PSCs激活有关的信号通路的研究结合最新进展作一综述。

Pancreatic fibrosis is one of the dominant pathological characters of chronic pancreatitis and pancreatic cancer.Activated pancreatic stellate cells（PSCs） play a pivotal role in pancreatic fibrosis.The activation of PSCs is regulated by several signaling transduction pathways： mitogen-activated protein kinases（MAPK）,phosphatidylinositol 3-kinase（PI3K）,Smad signaling transduction protein,peroxisome proliferator-activated receptor（PPAR）,Rho-ROCK.Identification of signaling molecules that play a crucial role in PSCs activation is important for the development of anti-fibrotic therapies.This review aims at summarizing the signaling transduction pathways that associated with the activation of PSCs and highlighting the recent advancements.