茶多酚辅助化疗治疗晚期非小细胞肺癌的临床研究

Clinical Research of Teapol Combined with Adjuvant Chemotherapy in the Treatment of Advanced Stage of Non-small-cell Lung Carcinoma

目的:观察茶多酚辅助化疗治疗晚期非小细胞肺癌的近期疗效及其对患者生活质量、中医临床症状的影响。方法:将57例晚期非小细胞肺癌患者随机分为试验组(化疗+茶多酚片,31例)和对照组(单纯化疗,26例)。治疗2个周期后,比较两组的有效率及治疗后的KPS评分、中医临床症状评分。结果:治疗结束后,试验组有效率(29.0%)较对照组(23.1%)高,但差异无统计学意义(P>0.05);试验组患者生活质量改善明显优于对照组(P<0.01);试验组在改善患者中医临床症状明显优于对照组(P<0.01)。结论:茶多酚片辅助化疗可改善晚期非小细胞肺癌患者的生活质量及中医临床症状,但在近期疗效方面无明显优势。

Objective：To observe the curative effect and effect on life quality and clinical symptoms of Teapol combined with adjuvant chemotherapy in the treatment of advanced stage of non-small-cell lung carcinoma.Methods：57 cases with non-small-cell lung carcinoma were randomly divided into trial group（chemotherapy with Teapol,31 cases） and control group（chemotherapy,26 cases）.Compare the total effective rate,KPS score and clinical symptoms evaluation of two groups after two cycles.Results：The effective power in trial group（29.0%） increased compared with control group（23.1%）,but the difference was not statistically significant（P〉0.05）.The life quality and clinical symptoms improvement of trial group were much better than control group（P〈0.01）.Conclusion：Teapol combined with adjuvant chemotherapy can improve the life quality and clinical symptoms of non-small-cell lung carcinoma in advanced stage,but without obvious advantages in the short-term.