乌司他丁治疗老年吸入性肺炎的临床分析

Clinical analysis of ulinastatin in treatment of aspiration pneumonia in the elderly

目的：观察乌司他丁对吸人性肺炎的治疗作用。方法分析我院2007年1月至2011年6月确诊为吸人性肺炎的住院病例60例，分成对照组和治疗组，治疗组加用乌司他丁，观察两组治疗前后临床症状及临床生化指标改变，以及患者预后情况。结果各组用药前C-反应蛋白（CRP）、白细胞（WBC）、体温、血气分析差异无统计学意义，分组后各组处理结果如下：治疗组与对照组死亡率、治愈率、平均住院时间、CRP、WBC、SaO2、PaO2差异均具有统计学意义（P＜0．05）。尤其CRP指标迅速下降。结论吸人性肺炎需尽早诊断、积极治疗、减少或者消除病因、合理用药，降低发病率及病死率。

Objective To observe the effects of ulinastatin on aspiration pneumonia. Methods Sixty patients in our hospital, who were diagnosed as aspiration pneumonia from January 2007 to June 2011, were randomly divided into routine treatment group and ulinastatin treatment group. The ulinastatin treatment group was given ulinastatin in addition. The changes of clinical symptoms and biochemical indexes in two groups were examined before and after treatment. Results There was no statistical difference in C-reactive protein （CRP）, white blood cell count （WBC）,body temperature and blood gas analysis before treatment between two groups. There was statistical significance in fatality rate, cure rate,the length of average hospital stays,CRP,WBC, SaO2 and PaO2 between treatment group and control group （ P〈 0.05）. Especially, CRP decreased rapidly. Conclusions It is needed in aspiration pneumonia that early diagnosis, active treatment, inducing or eliminating pathogen, taking medicine properly to reduce morbidity and mortality.