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组蛋白去乙酰化酶抑制剂的抗纤维化作用

Anti-fibrosis effect of histone deacetylase inhibitors
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摘要 组蛋白乙酰化／去乙酰化修饰是基因转录调控的关键机制之一，这种修饰作用分别由组蛋白乙酰转移酶和组蛋白去乙酰化酶调控，最近的研究表明组蛋白去乙酰化酶与一些以慢性纤维化为主要特征的疾病相关。而体内外实验证明组蛋白去乙酰化酶抑制剂可抑制纤维化反应。本文针对组蛋白去乙酰化酶抑制剂的抗纤维化作用作一综述。 Histone acetylation/deacetylation modification is the key mechanism for regulating gene transcription,and this modification is regulated by histone acetyltransferase and histone deacetylases. Recent studies have shown that histone deacetylases are related with the diseases mainly characterized by chronic fibrosis. It is shown that histone deacetylase inhibitors can inhibit fibrotic reaction in both vivo and vitro experiments. In this paper,the effects of histone deacetylase inbibitors on anti-fibrosis are reviewed.
作者 叶清 李燕芹
机构地区 上海交通大学医学院附属仁济医院呼吸科
出处 《国际呼吸杂志》 2012年第12期937-940,共4页 International Journal of Respiration
关键词 组蛋白去乙酰化酶抑制剂 抗纤维化 Histone deacetylase inhibitors Antifibrotic
分类号 R96 [医药卫生—药理学]
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参考文献28

  • 1Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem, 2001,70:81 - 120.
  • 2Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer, 2006,6 : 38-51.
  • 3Chen GQ, Zhu J, Shi XG,et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As203) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood, 1996,88:1052-1061.
  • 4Gregoretti IV, Lee YM, Goodson HV. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol, 2004,338 : 17-31.
  • 5夏靖,冯冰虹.组蛋白去乙酰化酶(HDACs)的研究进展[J].广东药学院学报,2010,26(5):546-550. 被引量：11
  • 6Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res, 2007, 5 : 981-989.
  • 7郭艳琳,康玉明,杨志明,王淑秋,秦达念.组蛋白脱乙酰化酶抑制剂对炎性细胞因子表达的影响[J].中国药物与临床,2010,10(4):365-368. 被引量：5
  • 8Glenisson W, Castronovo V, deacetylase 4 is required Waltregny D. Histone for TGFbetal induced myofibroblastic differentiation. Biochim Biophys Acta, 2007, 1773:1572-1582.
  • 9Guo W, Shan B, Klingsberg RC, et al. Abrogation of TGF- betal-indueed fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol, 2009,297 : L864-L870.
  • 10Coward WR, Watts K, Feghali-Bostwick CA,et al. Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol, 2009,29 .. 4325-4339.

二级参考文献47

  • 1谢爱华,廖晨钟,李伯玉,山松,邓沱,李志斌,宁志强,胡伟明,石乐明,周家驹,鲁先平.以组蛋白去乙酰化酶为靶标的抗癌药物研发进展[J].中国新药杂志,2005,14(1):10-14. 被引量：8
  • 2王生余,张旭辉,于晓妉.新型抗肿瘤药物组蛋白去乙酰化酶抑制剂[J].国际肿瘤学杂志,2006,33(6):404-406. 被引量：12
  • 3Adcock IM,Ford P,Ito K,et al.Epigenetics and airways disease.Respir Res,2006,7(1):21.
  • 4Xu WS,Parmigiani RB,Marks PA.Histone deacetylase inhibitors:molecular mechanism of action.Oncogene,2007,26(37):5541-5552.
  • 5Hayden MS,Ghosh S.Signaling to NF-κB.Genes Dev,2004,18(18):2195-2224.
  • 6Dong J,Jimi E,Zhong H,et al.Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.Genes Dev,2008,22(9):1159-1173.
  • 7Chen LF,Williams SA,Mu Y,et al.NF-kappaB RelA phosphorylation regulates RelA acetylation.Mol Cell Biol,2005,25(18):7966-7975.
  • 8Chen LF,Fischle W,Verdin E,et al.Duration of nuclear NF-κB action regulated by reversible acetylation.Science,2001,293(31):1653-1657.
  • 9Kiernan R,Brès V,Ng RW,et al.Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65.J Biol Chem,2003,278(4):2758-2766.
  • 10Hu J,Colburn NH.Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-κB/p65 DNA binding.Mol Cancer Res,2005,3(2):100-109.

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国际呼吸杂志
2012年 第12期

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