期刊文献+

大鼠脑缺血模型的建立与脑缺血致小肠损伤机制的探讨 被引量:2

Rat Cerebral Ischemia Model with Cerebral Ischemia Induced Intestinal Injury Mechanism
下载PDF
导出
摘要 目的:探讨脑缺血对小肠形态学的影响,为临床脑血管病患者防止小肠病变提供理论依据。方法:用线栓法栓塞大鼠右侧大脑中动脉制备局灶脑梗塞模型,在电子显微镜下观察脑缺血4小时后小肠的病理形态变化,并与正常对照组相比。结果:大脑中动脉栓塞后大鼠胃出现小肠绒毛变短变粗、杯状细胞增多及大量炎细胞浸润等病理形态学改变。结论:大脑中动脉栓塞后可引起小肠的相应病理学改变。 Objective:To investigate the effect of cerebral ischemia on small intestine morphology,as clinical cerebrovascular disease patients and provide theoretical basis for preventing intestinal lesions.Methods:With thread embolism of rat cerebral artery preparation of focal cerebral infarction model,under the electron microscope observation of cerebral ischemia and 4 hours after intestinal pathological changes,and compared with the normal control group.Results:Middle cerebral artery occlusion in rats after gastric intestinal villi become short and thick,goblet cells increased and the infiltration of inflammatory cells and other pathological changes.Conclusion:Middle cerebral artery after embolization can cause small intestinal corresponding pathological changes.
作者 高琳
出处 《中国伤残医学》 2012年第6期3-4,共2页 Chinese Journal of Trauma and Disability Medicine
关键词 脑缺血 小肠 病理改变 Cerebral ischemia Small intestine Pathological changes
  • 相关文献

参考文献7

  • 1载瑞鸿,林果为.内科学新理论与新技术[M].上海:上海科技教育出版社,1995:93:107.
  • 2Anderson R,Wang X,Sun Z,et al.Effect of a platelet-activating factor antagonist on pancreatitis-associzted gut barrier dysfunction in rats. Pancreas, 1998,17:107-119.
  • 3Dunger A, Augstein P,Schmidt S,et al.Identifieation of interleukin 1 induced apoptosis in rat islet using in situ specific labeling of fragmented DNA.Aut~immun, 1996,9:309-313.
  • 4Liu ZH,Striker GE,Stetler-Stevenson M,et aI.TNF- ct and IL-1 a induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cells.An J Physical,1996,279:C 1595-1601.
  • 5Jones BA,Gores GJ. Physiology and pathophysiology of apoptosis in epithelial cells of the liver,pancreas,and intestine. Am J Physiol, 1997, 273:G1174-1188.
  • 6Shah KA, Shurey S, Green CJ. Apoptosis after intestinal ischemia- reperfusion injury-a morphological study. Transplan- tation,1997, 64:1393 - 1397.
  • 7何龙泉,林莲初,陈文贵,张敬礼,王勇,帅正中.急性脑血管病血浆胃动素水平的初步研究[J].中风与神经疾病杂志,1995,12(1):15-16. 被引量:15

二级参考文献1

  • 1J. Ruscalleda,A. Peiró. Prognostic factors in intraparenchymatous hematoma with ventricular hemorrhage[J] 1986,Neuroradiology(1):34~37

共引文献14

同被引文献30

引证文献2

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部