2型糖尿病患者Pentraxin-3与尿白蛋白相关性的研究

Relationship between Pentraxin-3 and urinary albumin in type 2 diabetic patients

目的:分析2型糖尿病患者Pentraxin-3(PTX3)与尿白蛋白的相关性,探讨PTX3在糖尿病肾病中的作用。方法:2型糖尿病患者115例,根据尿白蛋白排泄率(UAER)分成正常白蛋白尿组、微量白蛋白尿组与临床白蛋白尿组,分别检测3组PTX3、血糖、血脂、HS-CRP、γ-谷氨酰转移酶等。结果:微量白蛋白尿组PTX3水平显著高于正常白蛋白尿组(P<0.01),临床白蛋白尿组PTX3水平显著高于正常白蛋白尿组和微量白蛋白尿组(P<0.01),PTX3与UAER呈正相关(r=0.667,P<0.01)。各组间年龄、FPG、TG、GGT、HS-CRP比较差异有统计学意义(P<0.05)。结论:PTX3水平与白蛋白尿相关,PTX3有助于糖尿病肾病的早期诊断。2型糖尿病患者PTX3水平升高是一个重要的危险因素。

Objective To investigate the relation of Pentraxin-3 （PTX3） and urinary albumin in type 2 diabetic patients, and to study the value of Pentraxin-3 in patients with diabetic nephropathy. Methods One hundred and fifteen patients with type 2 diabetes were divided into three groups according to UAER including normo- albuminuria, micro- albuminuria and macro-albuminuria. Pentraxin-3, FPG, lipids, HS-CRP and GGT were measured. Result PTX3 in micro-albuminuria was significantly higher than that in normo-albuminuria （P 〈 0.01 ）. PTX3 in macro-albuminuria was significantly higher than those in normo-albuminuria and micro-albuminuria （P 〈 0.01 ）. PTX3 was positively correlated with UAER（r = 0.667,P 〈 0.01 ）. Age, FPG, TG, GGT and HS-CRP were statistically different between three groups （P 〈 0.05 ）. Conclusions PTX3 was associated with albuminuria, PTX3 is helpful to the early diagnosis of diabetic nephropathy. PTX3 could play an important role for the increased risk of type 2 diabetic patients.