临床药师干预前后我院药品不良反应报告情况分析

Analysis of ADR Reports in Our Hospital before and after Clinical Pharmacist Intervention

目的:分析临床药师干预前、后我院药品不良反应(ADR)报告情况,探讨临床药师干预对ADR监测工作的影响。方法:将我院2008年(临床药师干预前)和2009年(临床药师干预后)上报的ADR报告,按报告人、给药途径、患者的年龄与性别、引起ADR的药品品种等进行分析、评价、比较。结果:2008年共上报ADR报告697份,其中新的严重的ADR98例,药师上报395例,临床医师上报92例,引起ADR最常见的药物为抗感染药,共375例,其中喹诺酮类药物113例;2009年共上报ADR报告599例,其中新的严重的ADR155例,药师上报327例,临床医师上报102例,引起ADR最常见的药物为抗感染药,共314例,其中喹诺酮类药物59例。结论:ADR监测工作可以促进临床安全、合理用药;临床药师在ADR监测工作中发挥着重要作用。

OBJECTIVE： To analyze ADR reports in our hospital before and after clinical pharmacist intervention, and to ex- plore the impact of clinical pharmacist intervention on ADR monitoring. METHODS： ADR reports of our hospital in 2008 （before intervention） and 2009 （after intervention） were analyzed and evaluated comparatively in respects of reporter, route of administration, patient＇ s age, sex and ADR-inducing drugs. RESULTS ： A total of 697 ADR cases were submitted in 2008, including 98 new/ serious ADR reports, 395 cases reported by pharmacists, 92 cases reported by clinician; the most common ADR-inducing drug was anti-infective drug, a total of 375 cases, of which 113 cases by quinolones. A total of 599 ADR cases were reported in 2009, including 155 new/serious ADR reports, 327 cases reported by pharmacists, 102 cases reported by clinician; the most common ADR-inducing drug was anti-infective drug, a total of 314 cases, of which 59 cases by quinolones. CONCLUSION： ADR monitoring can promote the rational safe use of drugs in the clinic; clinical pharmacists play an important role in ADR monitoring.